The increasing use of single-cell immune profiling and advanced microscopic imaging
technologies has deepened our understanding of the cardiac immune system, confirming …

Elevated pro-inflammatory biomarkers and cytokines are associated with morbidity and
mortality in heart failure (HF). Preclinical and clinical studies have shown multiple …

Aims After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils and
monocytes/macrophages to myocardium, which in turn initiates inflammatory and reparative …

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-
inflammatory to reparative responses, and the cardiac fibroblast is a central player during …

Abstract Dual-specificity phosphatase 6 (DUSP6) serves a specific and conserved function
on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). We …

Chronic heart failure is the end stage of cardiac diseases. With a high prevalence and a high
mortality rate worldwide, chronic heart failure is one of the heaviest health-related burdens …

Background Neutrophils are thought to be short‐lived first responders to tissue injuries such
as myocardial infarction (MI), but little is known about their diversification or dynamics …

Abstract Purpose of Review The aim of this review is to update the pathophysiological role of
innate immune response in the cardiovascular (CV) disease outcomes, particularly focusing …

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

Sterile tissue injury is thought to locally activate innate immune responses via damage-
associated molecular patterns (DAMPs). Whether innate immune pathways are remotely …