Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

People exposed to chronic stress age rapidly. The telomeres in their cells of all types
shorten faster. Inflammation is another important feature of stress that, along with aging …

Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …

Exposure to microgravity and ionizing radiation during spaceflight missions causes
excessive reactive oxygen species (ROS) production that contributes to cellular stress and …

Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere
erosion and mitochondrial injury, leading to impaired cellular functions and cell death …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Telomeres are DNA structures that protect chromosome ends. However, telomeres shorten
during cell replication and at critically low lengths can reduce cell replicative potential …

Alterations of mitochondrial and glycolytic energy pathways related to aging could contribute
to cerebrovascular dysfunction. We studied the impact of aging on energetics of primary …

Cellular adaptation to low-oxygen environments is mediated in part by the hypoxia-inducible
factors (HIFs). Like other transcription factors, the stability and transcriptional activity of HIFs …

Telomeres are repetitive DNA sequences at eukaryotic chromosome ends and function in
maintaining genome integrity and stability. These unique structures undergo shortening due …