Recombinant nucleic acids are considered as promising next-generation vaccines. These
vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated …

Single-stranded RNA viruses of both positive and negative polarity have been used as
vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus …

Alphavirus vectors are high-level, transient expression vectors for therapeutic and
prophylactic use. These positive-stranded RNA vectors, derived from Semliki Forest virus …

The threat of bioterrorism worldwide has accelerated the demand for the development of
therapies and vaccines against the Category B toxins: staphylococcal enterotoxin B (SEB) …

Alphavirus vectors have demonstrated high levels of transient heterologous gene
expression both in vitro and in vivo and, therefore, possess attractive features for vaccine …

On the basis of positive preclinical data, we evaluated the safety and immunogenicity of an
alphavirus replicon HIV-1 subtype C gag vaccine (AVX101), expressing a nonmyristoylated …

Vaccination represents the most effective control measure in the fight against infectious
diseases. Local mucosal immune responses are critical for protection from, and resolution …

Naturally occurring smallpox was eradicated as a result of successful vaccination
campaigns during the 1960s and 1970s. Because of its highly contagious nature and high …

We developed an intradermal (ID) challenge cynomolgus macaque (Macaca fascicularis)
model of scrub typhus, the leading cause of treatable undifferentiated febrile illness in …

Respiratory syncytial virus (RSV) is an important viral pathogen that causes severe lower
respiratory tract infection in infants, the elderly, and immunocompromised individuals. There …