[HTML][HTML] The role of epithelial damage in the pulmonary immune response
Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …
and are responsible for coordinating the innate immune response to injury and subsequent …
Lessons from ECLIPSE: a review of COPD biomarkers
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points
(ECLIPSE) study was a large 3-year observational controlled multicentre international study …
(ECLIPSE) study was a large 3-year observational controlled multicentre international study …
[HTML][HTML] Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary …
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction
JB Wilk, NRG Shrine, LR Loehr, JH Zhao… - American journal of …, 2012 - atsjournals.org
Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung
function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are …
function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are …
[HTML][HTML] A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic …
DT Cheng, DK Kim, DA Cockayne… - American journal of …, 2013 - atsjournals.org
Rationale: Emphysema in chronic obstructive pulmonary disease (COPD) can be
characterized by high-resolution chest computed tomography (HRCT); however, the …
characterized by high-resolution chest computed tomography (HRCT); however, the …
Genome-wide interaction analysis of air pollution exposure and childhood asthma with functional follow-up
A Gref, SK Merid, O Gruzieva, S Ballereau… - American journal of …, 2017 - atsjournals.org
Rationale: The evidence supporting an association between traffic-related air pollution
exposure and incident childhood asthma is inconsistent and may depend on genetic factors …
exposure and incident childhood asthma is inconsistent and may depend on genetic factors …
Pathological Implications of Receptor for Advanced Glycation End‐Product (AGER) Gene Polymorphism
M Serveaux-Dancer, M Jabaudon, I Creveaux… - Disease …, 2019 - Wiley Online Library
The receptor for advanced glycation end‐products (RAGE) is a cell surface transmembrane
multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is …
multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is …