Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis
Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …
The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis
G Wang, A Tanaka, H Zhao, J Jia, X Ma… - Hepatology …, 2021 - Springer
Guiqiang Wang1, 18· Atsushi Tanaka2· Hong Zhao1, 1 8· Jidong Jia3· Xiong Ma4· Kenichi
Harada5· Fu‑Sheng Wang6· Lai Wei7· Qixia Wang4· Ying Sun6· Yuan Hong1· Huiying …
Harada5· Fu‑Sheng Wang6· Lai Wei7· Qixia Wang4· Ying Sun6· Yuan Hong1· Huiying …
Optimising management strategies of inflammatory bowel disease in resource-limited settings in Asia
Over the 21st century, inflammatory bowel disease (IBD) has become a global disease with
increasing prevalence reported in the Asian subcontinent as a result of rapid urbanisation …
increasing prevalence reported in the Asian subcontinent as a result of rapid urbanisation …
Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia
Abstract Purpose Toxicity of 6-Mercaptopurine (6MP) is related to single nucleotide
polymorphism (SNP) in genes coding for metabolizing enzymes, with TPMT analysis being …
polymorphism (SNP) in genes coding for metabolizing enzymes, with TPMT analysis being …
Nucleoside diphosphate‐linked moiety X‐type motif 15 C415T variant as a predictor for thiopurine‐induced toxicity in Indian patients
Abstract Background and Aim Interindividual variation seen in the thiopurine metabolism is
attributed to the genetic variant in thiopurine methyltransferase (TPMT) gene leading to …
attributed to the genetic variant in thiopurine methyltransferase (TPMT) gene leading to …
A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics
S Saxena, TP Krishna Murthy, CR Chandrashekhar… - Scientific Reports, 2022 - nature.com
Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with
leukemia, inflammatory bowel diseases, and more. The objective of the present study was to …
leukemia, inflammatory bowel diseases, and more. The objective of the present study was to …
TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects
R Steponaitiene, J Kupcinskas, S Survilaite… - Advances in medical …, 2016 - Elsevier
Purpose Inter-individual thiopurine metabolism variability can influence treatment outcomes
in inflammatory bowel disease (IBD) patients. Genetic polymorphisms in thiopurine …
in inflammatory bowel disease (IBD) patients. Genetic polymorphisms in thiopurine …
Therapeutic drug monitoring in inflammatory bowel disease: A practical approach
D Desai - Indian Journal of Gastroenterology, 2024 - Springer
The global burden of inflammatory bowel diseases (IBD) is estimated at 4.9 million and the
global prevalence exceeds 0.3%. Multiple newer therapeutic agents have broadened the …
global prevalence exceeds 0.3%. Multiple newer therapeutic agents have broadened the …
Detailed resume of S-methyltransferases: Categories, structures, biological functions and research advancements in related pathophysiology and pharmacotherapy
H Mu, L Ye, B Wang - Biochemical Pharmacology, 2024 - Elsevier
Methylation is a vital chemical reaction in the metabolism of many drugs, neurotransmitters,
hormones, and exogenous compounds. Among them, S-methylation plays a significant role …
hormones, and exogenous compounds. Among them, S-methylation plays a significant role …
Pharmacogenetics of inflammatory bowel disease: a focus on Crohn's disease
S Rufini, C Ciccacci, G Novelli, P Borgiani - Pharmacogenomics, 2017 - Taylor & Francis
Crohn's disease is an inflammatory bowel disease showing a high heterogeneity in
phenotype and a strong genetic component. The treatment is complex, due to different …
phenotype and a strong genetic component. The treatment is complex, due to different …