Adamantanes for the treatment of neurodegenerative diseases in the presence of SARS-CoV-2

Z Pang, A Tang, Y He, J Fan, Q Yang… - Clinical Microbiology …, 2024 - journals.asm.org

SUMMARY SARS-CoV-2 can not only cause respiratory symptoms but also lead to
neurological complications. Research has shown that more than 30% of SARS-CoV-2 …

Assessing the Impact of Agents with Antiviral Activities on Transmembrane Ionic Currents: Exploring Possible Unintended Actions

GB Lin, CL Shih, R Liutkevičienė, V Rovite, EC So… - Biophysica, 2024 - mdpi.com

As the need for effective antiviral treatment intensifies, such as with the coronavirus disease
19 (COVID-19) infection, it is crucial to understand that while the mechanisms of action of …

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Amantadine mitigates the cytotoxic and genotoxic effects of doxorubicin in SH-SY5Y cells and reduces its mutagenicity

S Soares, JT de Sousa, FBM Boaretto, JB da Silva… - Toxicology in Vitro, 2024 - Elsevier

Amantadine (AMA) is a useful drug in neuronal disorders, but few studies have been
performed to access its toxicological profile. Conversely, doxorubicin (Dox) is a well-known …

[HTML][HTML] New anti-SARS-CoV-2 aminoadamantane compounds as antiviral candidates for the treatment of COVID-19

DP de Almeida Marques, LAF Andrade, EVS Reis… - Virus Research, 2024 - Elsevier

Here, the antiviral activity of aminoadamantane derivatives were evaluated against SARS-
CoV-2. The compounds exhibited low cytotoxicity to Vero, HEK293 and CALU-3 cells up to a …

Оценка воздействия полициклических производных каркасного ряда на репликативные свойства вируса SARS-CoV-2 в эксперименте in vitro

ОС Залевская, ВА Ширяев… - Проблемы особо …, 2024 - journal.microbe.ru

о.с. Залевская1, В.а. Ширяев2, Ю.н. климочкин2, с.ф. семенов1, л.П. родионова Page 1
148 Проблемы особо опасных инфекций. 2024; 1 ОРигинальнЫе статьи DOI: 10.21055/0370-1069-2024-1-148-153 …