FBN1-related Marfan syndrome (Marfan syndrome), a systemic disorder of connective tissue
with a high degree of clinical variability, comprises a broad phenotypic continuum ranging …

Disease of the aortic arch, descending thoracic, or thoracoabdominal aorta necessitates
dedicated expertise across medical, endovascular, and surgical specialties. Cardiologists …

Marfan syndrome (MFS) is an autosomal dominant condition characterized by aortic
aneurysm, skeletal abnormalities, and lens dislocation, and is caused by variants in the …

Background Marfan syndrome (MFS) is a genetic disorder leading to medial aortic
degeneration and life-limiting dissections. To date, there is no causal prevention or therapy …

Hereditary thoracic aortic diseases (HTAD) such as Marfan syndrome (MFS), Loeys–Dietz
syndrome (LDS), and vascular Ehlers–Danlos syndrome (VEDS) frequently result in …

马方综合征是一种常染色体显性遗传的多系统结缔组织疾病， 主要由FBN1 基因突变所致，
临床表现不一， 新生儿马方综合征尤其罕见， 病情重， 预后差。 目前， 尚无针对马方综合征的 …

Marfan syndrome (MFS) is a multisystem conncctivc tissue disease with autosomal dominant
inheritance. It is mainly caused by FBN1 gene mutation and often has different clinical …

ABSTRACT BACKGROUND Drug options for the treatment of Marfan syndrome (MFS) still
warrant further investigation. Beta-blockers (BB) have long been considered the standard …

Background: Marfan Syndrome (MFS) is a monogenic multisystem disorder resulting from
mutations in fibrillin-1, resulting in thoracic aortic aneurysm. Currently, effective treatments …