Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

The role of B cells in anti-tumour immunity is still debated and, accordingly,
immunotherapies have focused on targeting T and natural killer cells to inhibit tumour …

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …

Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-
year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with …

Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and
an extremely high mortality rate. Here, we performed whole-exome sequencing, RNA …

Abstract Alpha-fetoprotein (AFP)-secreting hepatocellular carcinoma (HCC), which accounts
for~ 75% of HCCs, is more aggressive with a worse prognosis than those without AFP …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Abstract Background Dendritic cells (DCs) mediate divergent immune effects by activating T
cells or negatively regulating the immune response to promote immune tolerance. They …

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …