Background Cognitive impairment, a defining feature of dementia, plays an important role in
the compromised functional independence that characterises the condition. Cognitive …

The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with
repetitive head impacts (RHI), but the components of RHI exposure underlying this …

Importance Players of American football may be at increased risk of long-term neurological
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …

Background Cerebrospinal fluid biomarker profiles characterized by decreased amyloid-
beta peptide levels and increased total and phosphorylated tau levels at threonine 181 …

Background It is essential to determine the specificity of AV-1451 PET for tau in brain
imaging by using pathological comparisons. We performed autoradiography in autopsy …

Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases
are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from …

The potential for positron emission tomography (PET) to detect neuroinflammation in vivo
has sparked a remarkable interest in various disciplines of neuroscience. Early PET …

The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated
to combine both patient care and research. Together, to date, all patients forming the …