Rationale and efficacy of sound therapies for tinnitus and hyperacusis

M Pienkowski - Neuroscience, 2019 - Elsevier
Sound therapies are a common component of treatments for tinnitus and hyperacusis. The
original idea was to partially or completely mask tinnitus with broadband noise delivered by …

Objective detection of tinnitus based on electrophysiology

S Fan, S Li - Brain Sciences, 2022 - mdpi.com
Tinnitus, a common disease in the clinic, is associated with persistent pain and high costs to
society. Several aspects of tinnitus, such as the pathophysiology mechanism, effective …

Remodeling of cholinergic input to the hippocampus after noise exposure and tinnitus induction in Guinea pigs

L Zhang, C Wu, DT Martel, M West, MA Sutton… - …, 2019 - Wiley Online Library
Here, we investigate remodeling of hippocampal cholinergic inputs after noise exposure and
determine the relevance of these changes to tinnitus. To assess the effects of noise …

Noise exposure alters glutamatergic and GABAergic synaptic connectivity in the hippocampus and its relevance to tinnitus

L Zhang, C Wu, DT Martel, M West, MA Sutton… - Neural …, 2021 - Wiley Online Library
Accumulating evidence implicates a role for brain structures outside the ascending auditory
pathway in tinnitus, the phantom perception of sound. In addition to other factors such as …

Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus

A Hockley, JI Berger, AR Palmer… - European Journal of …, 2020 - Wiley Online Library
Previous work has led to the hypothesis that, during the production of noise‐induced
tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase …

[HTML][HTML] Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs

CA Wilson, JI Berger, J de Boer, M Sereda, AR Palmer… - Hearing research, 2019 - Elsevier
A common method for measuring changes in temporal processing sensitivity in both humans
and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also …

Identifying tinnitus in mice by tracking the motion of body markers in response to an acoustic startle

MN Wallace, JI Berger, A Hockley, CJ Sumner… - Frontiers in …, 2024 - frontiersin.org
Rodent models of tinnitus are commonly used to study its mechanisms and potential
treatments. Tinnitus can be identified by changes in the gap-induced prepulse inhibition of …

Using extracochlear multichannel electrical stimulation to relieve tinnitus and reverse tinnitus-related auditory-somatosensory plasticity in the cochlear nucleus

M Chen, S Min, C Zhang, X Hu, S Li - Neuromodulation: Technology at the …, 2022 - Elsevier
Objectives Tinnitus has no reliable cure but may be significantly relieved by the usage of
cochlear implants. However, not all tinnitus patients necessitate cochlear implantation that …

Tinnitus-related increases in single-unit activity in awake rat auditory cortex correlate with tinnitus behavior

R Cai, L Ling, M Ghimire, KA Brownell, DM Caspary - Hearing Research, 2024 - Elsevier
Tinnitus is known to affect 10–15% of the population, severely impacting 1–2% of those
afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage …

Does tinnitus fill in the gap using electrophysiology? A scoping review

V Duda, O Scully, MS Baillargeon… - … Clinics of North America, 2020 - oto.theclinics.com
Tinnitus is a phenomenon in which a sound is heard by an individual without the presence
of external acoustic stimulation. Its origin is still a subject of much debate as there is currently …