[HTML][HTML] Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

[HTML][HTML] Long COVID or Post-COVID-19 Condition: Past, Present and Future Research Directions

C Fernández-de-Las-Peñas, AV Raveendran… - Microorganisms, 2023 - mdpi.com
The presence of symptoms after an acute SARS-CoV-2 infection (long-COVID) has become
a worldwide healthcare emergency but remains underestimated and undertreated due to a …

Challenges and opportunities in long COVID research

RE Hamlin, CA Blish - Immunity, 2024 - cell.com
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-
CoV-2 infection but rather have persistent or new symptoms for months to years following …

[HTML][HTML] Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C] PBR28 PET correlates with vascular disease measures

MB VanElzakker, HF Bues, L Brusaferri, M Kim… - Brain, Behavior, and …, 2024 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public
health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long …

Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study

H Wang, Y Wei, CT Hung, G Lin, X Jiang… - The Lancet Infectious …, 2024 - thelancet.com
Background Studies have established the short-term efficacy of nirmatrelvir–ritonavir in
managing COVID-19, yet its effect on post-COVID-19 condition, especially in patients …

The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China

W Zuo, D He, C Liang, S Du, Z Hua, Q Nie… - The Lancet Infectious …, 2024 - thelancet.com
Background Growing evidence suggests that symptoms associated with post-COVID-19
condition (also known as long COVID) can affect multiple organs and systems in the human …

[HTML][HTML] SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids

R Stewart, K Yan, SA Ellis, CR Bishop… - Frontiers in …, 2023 - frontiersin.org
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …

Long COVID research risks losing momentum–we need a moonshot

L McCorkell, MJ Peluso - Nature, 2023 - nature.com
Long COVID research risks losing momentum – we need a moonshot Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial

LN Geng, H Bonilla, H Hedlin, KB Jacobson… - JAMA Internal …, 2024 - jamanetwork.com
Importance There is an urgent need to identify treatments for postacute sequelae of SARS-
CoV-2 infection (PASC). Objective To assess the efficacy of a 15-day course of nirmatrelvir …

[PDF][PDF] Presence of viral spike protein and vaccinal spike protein in the blood serum of patients with long-COVID syndrome

K Dhuli, MC Medori, C Micheletti… - Eur Rev Med …, 2023 - europeanreview.org
OBJECTIVE: COVID-19 patients experience, in 10-20% of the cases, a prolonged long-
COVID syndrome, defined as the persistence of symptoms for at least two months after the …