[HTML][HTML] SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids

R Stewart, K Yan, SA Ellis, CR Bishop… - Frontiers in …, 2023 - frontiersin.org
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …

Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study

H Wang, Y Wei, CT Hung, G Lin, X Jiang… - The Lancet Infectious …, 2024 - thelancet.com
Background Studies have established the short-term efficacy of nirmatrelvir–ritonavir in
managing COVID-19, yet its effect on post-COVID-19 condition, especially in patients …

[PDF][PDF] Presence of viral spike protein and vaccinal spike protein in the blood serum of patients with long-COVID syndrome

K Dhuli, MC Medori, C Micheletti… - Eur Rev Med …, 2023 - europeanreview.org
OBJECTIVE: COVID-19 patients experience, in 10-20% of the cases, a prolonged long-
COVID syndrome, defined as the persistence of symptoms for at least two months after the …

[HTML][HTML] Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms: a systematic review of the literature

C Fernández-de-Las-Peñas… - Clinical Chemistry and …, 2024 - degruyter.com
Introduction Viral persistence is one of the main hypotheses explaining the presence of post-
COVID symptoms. This systematic review investigated the presence of SARS-CoV-2 RNA in …

[HTML][HTML] Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection

MJ Peluso, ZN Swank, SA Goldberg, S Lu, T Dalhuisen… - Medrxiv, 2023 - ncbi.nlm.nih.gov
BACKGROUND: Persistent symptoms among some persons who develop COVID-19 has
led to the hypothesis that SARS-CoV-2 may, in some form or location, persist for long …

Unraveling links between chronic inflammation and long COVID: workshop report

P Tandon, ND Abrams, LR Avula… - The Journal of …, 2024 - journals.aai.org
As COVID-19 continues, an increasing number of patients develop long COVID symptoms
varying in severity that last for weeks, months, or longer. Symptoms commonly include …

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

MJ Peluso, D Ryder, RR Flavell, Y Wang… - Science Translational …, 2024 - science.org
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …

[HTML][HTML] Transcranial direct current stimulation (tDCS) in the treatment of neuropsychiatric symptoms of long COVID

M Klírová, A Adamová, N Biačková, O Laskov… - Scientific Reports, 2024 - nature.com
The study aimed to assess the efficacy of transcranial direct current stimulation (tDCS) in the
treatment of neuropsychiatric (NP) symptoms of the post-acute sequelae of SARS-CoV-2 …

[HTML][HTML] Intra-host evolution analyses in an immunosuppressed patient supports SARS-CoV-2 viral reservoir hypothesis

D Fournelle, F Mostefai, E Brunet-Ratnasingham… - Viruses, 2024 - mdpi.com
Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been
identified, many of which share recurrent mutations in the spike glycoprotein's receptor …

Is there a role for growth hormone replacement in adults to control acute and post-acute COVID-19?

N Venugopal, PA Armstrong, TJ Wright… - Best Practice & …, 2023 - Elsevier
The SARS-CoV-2 pandemic created a multitude of medical crossroads requiring real time
adaptations of best practice covering preventative and interventional aspects of care. Among …