Immunotherapy is leading a paradigm shift in the treatment of various diseases, including
tumors, auto‐immune diseases, and infectious diseases. However, the limited response rate …

Abstract FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and
homeostasis of the immune system. The molecular mechanisms underlying the stability …

Background Dysfunction of regulatory T (Treg) cells has been detected in diverse
inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is …

BACKGROUND & AIMS: New therapeutic strategies are needed for patients with refractory
Crohn's disease (CD). We evaluated data from the Crohn's And Treg Cells Study (CATS1) to …

T‐cell immunoglobulin and mucin domain 3 (TIM‐3) is an Ig‐superfamily member expressed
on IFN‐γ‐secreting Th1 and Tc1 cells and was identified as a negative regulator of immune …

Purpose: Although the central role of the immune system for tumor prognosis is generally
accepted, a single robust marker is not yet available. Experimental Design: On the basis of …

It is estimated that, of the 7.9 million fractures sustained in the United States each year, 5%
to 20% result in delayed or impaired healing requiring therapeutic intervention. Following …

Regulatory T cells (Tregs) play a central role in the induction and maintenance of immune
homeostasis and self-tolerance. Tregs constantly express the high-affinity receptor to IL-2. IL …

T-regulatory cells (Tregs) are a rare lymphocyte subtype that shows promise for treating
infectious disease, allergy, graft-versus-host disease, autoimmunity and asthma. Clinical …

The identification of T‐helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD 4+ T cells
has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many …