Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

[HTML][HTML] Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases

T Sun, H Yu, D Li, H Zhang, J Fu - Redox Biology, 2023 - Elsevier
Oxygen therapy is common during the neonatal period to improve survival, but it can
increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in …

Endothelial to mesenchymal transition during neonatal hyperoxia‐induced pulmonary hypertension

J Gong, Z Feng, AL Peterson, JF Carr… - The Journal of …, 2020 - Wiley Online Library
Bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants, results
from mechanical ventilation and hyperoxia, amongst other factors. Although most BPD …

How lung injury and therapeutic oxygen could alter white matter development

RW Dettman, MLV Dizon - Journal of neuroscience research, 2022 - Wiley Online Library
Developmental brain injury describes a spectrum of neurological pathologies resulting from
either antenatal or perinatal injury. This includes both cognitive and motor defects that affect …

[HTML][HTML] Hyperoxia induced bronchopulmonary dysplasia-like inflammation via miR34a-TNIP2-IL-1β pathway

X Tao, L Mo, L Zeng - Frontiers in Pediatrics, 2022 - frontiersin.org
Lung injury induced by oxygen is a key contributor to the pathogenesis of preterm infant
bronchopulmonary dysplasia (BPD). To date, there are comprehensive therapeutic strategy …

Inhibition of FABP4 attenuates hyperoxia‐induced lung injury and fibrosis via inhibiting TGF‐β signaling in neonatal rats

LT Huang, HC Chou, CM Chen - Journal of Cellular Physiology, 2022 - Wiley Online Library
Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by interrupted
alveologenesis and alveolar simplification caused by oxygen therapy in premature infants …

[HTML][HTML] Neonatal extracellular superoxide dismutase knockout mice increase total superoxide dismutase activity and VEGF expression after chronic hyperoxia

M Mathias, J Taylor, E Mendralla, M Perez - Antioxidants, 2021 - mdpi.com
Bronchopulmonary dysplasia (BPD) is a common lung disease affecting premature infants
that develops after exposure to supplemental oxygen and reactive oxygen intermediates …

Therapies that enhance pulmonary vascular NO-signaling in the neonate

J Dillard, M Perez, B Chen - Nitric Oxide, 2020 - Elsevier
There are several pulmonary hypertensive diseases that affect the neonatal population,
including persistent pulmonary hypertension of the newborn (PPHN) and bronchopulmonary …

Repurposing of the PDE5 Inhibitor Sildenafil for the Treatment of Persistent Pulmonary Hypertension in Neonates

EL Poitras, SL Gust, PM Kerr… - Current Medicinal …, 2021 - ingentaconnect.com
Nitric oxide (NO), an important endogenous signaling molecule released from vascular
endothelial cells and nerves, activates the enzyme soluble guanylate cyclase to catalyze the …

Oxidative stress in neonatal lung diseases

RJ Teng - Oxidative Stress in Lung Diseases: Volume 1, 2019 - Springer
Neonates experience abrupt surge in oxygen (O 2) tension immediately after birth when
their antioxidant defense system is not yet fully established. The more than fivefold increase …