Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked
clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …

The term'endocannabinoid'—originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from
eating disorders to rabies. However, as newer, more effective drugs were discovered and as …

Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …

Excessive inflammatory responses can emerge as a potential danger for organisms' health.
Physiological balance between pro-and anti-inflammatory processes constitutes an …

2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid …

Background & Aims: Two G-protein—coupled cannabinoid receptors, termed CB1 and CB2,
have been identified and several mammalian enteric nervous systems express CB1 …

There are at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled.
CB1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …