While most of the studies concerning the role of cannabinoids on gastric motility have
focused the attention on the gastric emptying in in vivo animal models, there is little …

Abstract Purpose of Review Complementary therapies for inflammatory bowel disease (IBD)
have earned growing interest from patients and investigators alike, with a dynamic …

Food intake depends on a tightly controlled interplay of appetite hormones and the enteric
(ENS) and central nervous system. Corticosterone (CORT) levels, which are mainly studied …

Background Constipation is one of the most common chronic digestive complaints.
Gastrointestinal transit studies have divided it into three patterns: normal transit, slow transit …

Abstract Background and Aim The endocannabinoid system is involved in the
pathophysiology of irritable bowel syndrome (IBS). Here, we investigated whether genetic …

SUMMARY 1 TAK242 is a novel compound that suppresses nitric oxide and cytokine
production by selectively inhibiting intracellular signals from tolllike receptor (TLR)4. In the …

Cannabinoid receptors are fundamentally involved in all aspects of intestinal physiology,
such as motility, secretion, and epithelial barrier function. They are part of a broader entity …

Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of several important
endogenous fatty acid amides (FAAs), including anandamide, oleoylethanolamide and …

Background Hemopressin was identified as an endogenous inverse agonist/antagonist of
CB 1 receptor, whereas VDhemopressin (α)[VDHpα] and VDhemopressin (β)[VDHpβ] …

Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor
of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be …