This article summarizes the ongoing challenges in irritable bowel syndrome and the exciting
opportunities for development of novel therapies for this common, enigmatic condition. The …

Ulcerative colitis (UC) is a chronic inflammatory process that is occasionally associated with
complications that cause significant morbidity and mortality. Studies in experimental animal …

Abstract Cannabinoid-1 (CB 1) receptors on myenteric neurons are involved in the
regulation of intestinal motility. Our aim was to investigate CB 1 receptor involvement in …

Palmitoylethanolamide (PEA) as well as the other N-acylethanolamines (NAEs), eg
anandamide, oleoylethanolamide, stearoylethanolamide and linoleoylethanolamide, appear …

Background Cannabinoids acutely administered depress central, cardiovascular and
gastrointestinal functions. These effects might be modified upon repeated administration …

The endocannabinoid system (ECS) is composed of endogenous cannabinoids;
components involved in their synthesis, transport, and degradation; and an expansive …

Background: Cannabis has a very extensive history of its uses as a medicinal plant that
likely dates back more than two millennia. This review was envisioned to provide a brief …

Diacylglycerol lipases (DGLs) mainly catalyze “on-demand” biosynthesis of bioactive
monoacylglycerols (MAGs) with different long fatty acyl chains, including 2 …

The use of cannabinoids to treat gastrointestinal (GI) motor disorders has considerable
potential. However, it is not clear if tolerance to their actions develops peripherally, as it does …

Cannabinoids and their receptors play a significant role in the regulation of gastrointestinal
(GIT) peristalsis and intestinal barrier permeability. This review critically evaluates current …