The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and
cyclin-dependent kinase 9 that regulate the elongation phase of transcription by RNA …

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies
showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the …

Human infection with highly pathogenic avian influenza viruses (HPAIV) is often associated
with severe tissue damage due to hyperinduction of interferons and proinflammatory …

The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA
Polymerase II (RNAPII) transcription in metazoa. Comprised of the noncoding 7SK RNA …

Background: The viral transactivator Tat protein is a key modulator of HIV-1 replication, as it
regulates transcriptional elongation from the integrated proviral genome. Tat recruits the …

Regulation of RNA polymerase II (RNAPII) activity is an essential process that governs gene
expression; however, its contribution to the fundamental process of erythropoiesis remains …

We describe here the identification and functional characterization of the enzyme O-
GlcNAcase (OGA) as an RNA polymerase II elongation factor. Using in vitro transcription …

Background Next-generation sequencing (NGS) approaches are commonly used to identify
key regulatory networks that drive transcriptional programs. Although these technologies are …

Malignant pleural mesothelioma (MPM) is a rare and incurable cancer, which incidence is
increasing in many countries. MPM escapes the classical genetic model of cancer evolution …

The 7SK ribonucleoprotein (RNP) is a critical regulator of eukaryotic transcription. Recently,
RNA binding motif 7 (RBM7) containing an RNA recognition motif (RRM) was reported to …