Mismatch repair (MMR)–deficient colorectal cancers (dMMR colorectal cancer) are
characterized by the expression of highly immunogenic neoantigen peptides, which …

Many studies have demonstrated the effects of exercise on both primary and secondary
prevention of colon cancer. Exercise appears to have a dose-response reduction in the rate …

NR4A2 is a transcription factor belonging to the steroid orphan nuclear receptor superfamily.
It was originally considered to be essential in the generation and maintenance of …

Background Frequent use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been
shown to reduce the risk of colorectal adenomas in randomized trials. We examined the …

Background NR4A2, an orphan nuclear receptor essential in neuron generation, has been
recently linked to inflammatory and metabolic pathways of colorectal carcinoma (CRC) …

Increased production of the pro-inflammatory enzyme cyclooxygenase-2 (Cox-2) and altered
expression and activity of peroxisome proliferator-activated receptor γ (PPARγ) have been …

Purpose: Prognosis of patients with colorectal cancer (CRC) is associated with systemic
inflammation, and anti-inflammatory drugs can reduce both CRC incidence and mortality …

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) and hormone therapy (HT)
independently decrease the risk of colorectal cancer. However, their role in altering survival …

Background Homeodomain-interacting protein kinase 2 (HIPK2) is a multifunctional protein
that exploits its kinase activity to modulate key molecular pathways in cancer to restrain …

The incidence of squamous cancer of the esophagus varies up to a hundredfold in different
regions of the world. In Transkei, South Africa, a particularly high incidence of the disease is …