The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …

Background: Risk factors of drug-induced nephrotoxicity include drug overdose, drug-drug
interactions and drug-related adverse effects. Since the usage of some nephrotoxic drugs is …

Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI).
Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI …

Hepatitis B virus (HBV) infection is the commonest cause of chronic hepatitis, with an
estimated global prevalence of 3.5%, and which leads to significant morbidity and mortality …

Abstract Background Hepatitis B virus (HBV) infection is a significant global health problem
and> 42–52% of patients are infected during perinatal period. Tenofovir alafenamide …

Modern ART has now achieved the goal of maintaining HIV RNA suppression with minimum
drug-related toxicities. Indeed, in high-income settings, the main health issues in adult …

Fanconi's Syndrome (FS) is a disorder characterized by impaired renal proximal tubule
function. FS is associated with a vast defect in the renal reabsorption of several chemicals …

A variety of marketed drugs belonging to various therapeutic classes are known to cause
nephrotoxicity. Nephrotoxicity can manifest itself in several forms depending on the specific …

Background Since the beginning of highly active antiretroviral therapy utilization, the
association of renal impairment with treatment toxicity is more prevalent. Tenofovir disoproxil …

Background Drug-induced nephrotoxicity is a frequent adverse event that can lead to acute
or chronic kidney disease and increase the healthcare expenditure. It has high morbidity …