Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling

P Ramesh, R Jagadeesan, S Sekaran… - Frontiers in …, 2021 - frontiersin.org
Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea
plants, and stems and many more natural commodities. They have a multitude of …

Metabolic hallmarks of hepatic stellate cells in liver fibrosis

O Khomich, AV Ivanov, B Bartosch - Cells, 2019 - mdpi.com
Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Wnt signaling pathway in aging-related tissue fibrosis and therapies

HH Hu, G Cao, XQ Wu, ND Vaziri, YY Zhao - Ageing research reviews, 2020 - Elsevier
Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

[HTML][HTML] Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell

Z Zhang, S Zhao, Z Yao, L Wang, J Shao, A Chen… - Redox biology, 2017 - Elsevier
Activation of hepatic stellate cells (HSCs) is a pivotal event in liver fibrosis, characterized by
dramatic disappearance of lipid droplets (LDs). Although LD disappearance has long been …

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling …

J Dai, R Wei, P Zhang, B Kong - Journal of translational medicine, 2019 - Springer
Background Ovarian cancer (OC) is one of the leading causes for cancer-related deaths
among women. MicroRNAs (miRs) have been proved to be vital to the development and …

Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis

J Wang, L Li, L Li, Q Yan, J Li, T Xu - Gene, 2018 - Elsevier
Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

[HTML][HTML] CCAAT/enhancer-binding proteins in fibrosis: Complex roles beyond conventional understanding

L Wang, J Feng, Y Deng, Q Yang, Q Wei, D Ye, X Rong… - Research, 2022 - spj.science.org
CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified
transcription factors that contain a highly conserved basic leucine zipper domain and …

Curcumin inhibits the activity and induces apoptosis of activated hepatic stellate cell by suppressing autophagy

Y Shu, Y He, G Ye, X Liu, J Huang… - Journal of cellular …, 2023 - Wiley Online Library
Curcumin, a kind of natural compound, has been previously proven to inhibit the autophagy
in hepatic stellate cells (HSCs) and induce their apoptosis. However, it is not clear whether …

Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma

X Yang, JN Lv, H Li, B Jiao, QH Zhang, Y Zhang… - Journal of …, 2017 - Taylor & Francis
Objectives: Asthma is a chronic inflammatory, heterogeneous airway disease affecting
millions of people around the world. Curcumin has been found to have anti-inflammatory …

The role of WNT/β-catenin signaling pathway and glutamine metabolism in the pathogenesis of CCl4-induced liver fibrosis: repositioning of niclosamide and concerns …

NE El-Ashmawy, GM Al-Ashmawy, HE Fakher… - Cytokine, 2020 - Elsevier
Background Liver fibrosis is a serious health problem which may lead to advanced liver
cirrhosis and hepatocellular carcinoma. Objective The present study aimed to investigate the …