The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …

The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox
homeostasis by controlling the expression of many endogenous antioxidants and phase II …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Sesquiterpene lactones (SL), characterized by their high prevalence in the Asteraceae
family, are one of the major groups of secondary metabolites found in plants. Researchers …

Abstract Background and Rationale The dynorphin/kappa opioid receptor (KOR) system has
been implicated as a critical component of the stress response. Stress-induced activation of …

Although membrane trafficking pathways are involved in basic cellular functions, the
evolutionally expanded number of their related family proteins suggests additional roles for …

Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation.
Identifying protein targets of ROS can provide insight into uncharacterized ROS-regulated …

Emerging evidence suggests that many proteins may be regulated through cysteine
modification, but the extent and functions of this signaling remain largely unclear. The …

Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …

Malignant melanoma is one of the most deadly skin cancer, due to its aggressive
proliferation and metastasis. Naringenin, abundantly present in citrus fruits, has widely …