Metabolic dysregulation contributes to the progression of Alzheimer's disease

X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

[HTML][HTML] Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase

B Liu, J Kou, F Li, D Huo, J Xu, X Zhou, D Meng… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The lemon essential oil (LEO), extracted from the fruit of lemon, has been used to treat
multiple pathological diseases, such as diabetes, inflammation, cardiovascular diseases …

Quantitative metabolomic analysis reveals the fractionation of active compounds during lemon fruit juicing

Z Zhu, J Wang, L Tang, J Tang, D Liu, F Geng - Food Research International, 2023 - Elsevier
In this study, metabolomic analysis was employed to investigate the separation
(fractionation) of active compounds into lemon juice (LJ) and lemon pomace (LP) during …

Cognitive facilitation and antioxidant effects of an essential oil mix on scopolamine-induced amnesia in rats: Molecular modeling of in vitro and in vivo approaches

RS Boiangiu, I Brinza, M Hancianu, I Erdogan Orhan… - Molecules, 2020 - mdpi.com
The present study investigated the capability of an essential oil mix (MO: 1% and 3%) in
ameliorating amnesia and brain oxidative stress in a rat model of scopolamine (Sco) and …

Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K …

R Wang, Z Zhang, M Kumar, G Xu… - … design, development and …, 2019 - Taylor & Francis
Background The aim of the current experimental study was to scrutinize the neuroprotective
effect of ketamine on the isoflurane (iso)-induced cognitive dysfunction in rats via …

Lemon juice bioactivity in vitro increased with lactic acid fermentation

CY Hsieh, SL Hsieh, JY Ciou, YW Huang… - … Journal of Food …, 2021 - Taylor & Francis
This study compares the antioxidant capacity of non-sterilized lemon product (NLFP) and
sterilized lemon fermented product (LFP). After gastrointestinal simulation reaction, the …

Protective effect of hyperforin on β amyloid protein induced apoptosis in PC12 cells and colchicine induced Alzheimer's disease: an anti-oxidant and anti-inflammatory …

X Jiang, M Kumar, Y Zhu - Journal of Oleo Science, 2018 - jstage.jst.go.jp
The current investigation aimed to scrutinize the neuro-protective effect of hyperforin on β‑
amyloid peptide (Aβ) 1-42 and H 2 O 2 induced injury in PC12 cells and colchicine induced …

Protective effect of Monarda didymaL. essential oil and its main component thymol on learning and memory impairment in aging mice

Y Guo, Y Qu, W Li, H Shen, J Cui, J Liu, J Li… - Frontiers in …, 2022 - frontiersin.org
The aging process of human beings is accompanied by the decline of learning and memory
ability and progressive decline of brain function, which induces Alzheimer's Disease (AD) in …

Potential therapeutic natural compounds for the treatment of Alzheimer's disease

Q Huang, W Wu, Y Wen, S Lu, C Zhao - Phytomedicine, 2024 - Elsevier
Background Alzheimer's disease (AD) is a complicated neurodegenerative disease with
cognitive impairment occurring in the older people, in which extracellular accumulation of β …

Investigating the Potential of Essential Oils from Citrus reticulata Leaves in Mitigating Memory Decline and Oxidative Stress in the Scopolamine-Treated Zebrafish …

I Brinza, RS Boiangiu, I Honceriu, AM Abd-Alkhalek… - Plants, 2024 - mdpi.com
Petitgrain essential oil (PGEO) is derived from the water distillation process on mandarin
(Citrus reticulata) leaves. The chemical constituents of PGEO were analyzed by gas …