Drugs are typically small molecules that are generally classified as xenobiotics, which are
foreign to the human body. Several endogenous molecules, however, such as steroids and …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

Cardiovascular disease complicating pregnancy is rising in prevalence secondary to
advanced maternal age, cardiovascular risk factors, and the successful management of …

The extensive metabolic demands of pregnancy require specific physiological and
anatomical changes. These changes affect almost all organ systems, including the …

Background The rationale behind this update of the 2016 British Society for Rheumatology
(BSR) guidelines on prescribing anti-rheumatic drugs in pregnancy and breastfeeding [1, 2] …

Alzheimer's disease (AD) is characterized by high heterogeneity in disease manifestation,
progression and risk factors. High phenotypic variability is currently regarded as one of the …

ABSTRACT Introduction: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein
(BCRP)/ABCG2 are highly expressed in the placenta and fetus throughout gestation and …

Intramuscular injection of long-acting cabotegravir and rilpivirine is a novel, long-acting
antiretroviral therapy (ART) combination approved for use as a fully suppressive regimen for …

This international multidisciplinary expert consensus statement is intended to provide
comprehensive guidance that can be referenced at the point of care to cardiac …

Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I
biotransformation. The most important role in biotransformation belongs to CYP3A4 …