Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

Cancer development is essentially a tissue remodeling process in which normal tissue is
substituted with cancer tissue. A crucial role in this process is attributed to proteolytic …

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-
related protein that functions as a tumor suppressor. We found that merlin mediates contact …

The evolution of animals (metazoans) from their unicellular ancestors required the
emergence of novel mechanisms for cell adhesion and cell–cell communication. One of the …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Melanoma chondroitin sulphate proteoglycan (MCSP) is a cell-surface antigen that has
been implicated in the growth and invasion of melanoma tumours. Although this antigen is …

The shedding of membrane vesicles from the cell surface is a vital process considered to be
involved in cell-cell and cell-matrix interactions and in tumor progression. By …

Bone cells transduce mechanical signals into anabolic biochemical responses. However,
the mechanisms of mechanotransduction are unknown. To address this issue, we performed …

1. BACKGROUND This chapter will focus on the role of adhesion molecules in ovarian
carcinoma. Specifically, we will focus on the interactions that occur between ovarian …

The malignant progression of tumors is thoughtto be related to the expression of oncogenes
and loss ofexpression of tumor suppressor gene. These factors areintrinsic to the cancer …