Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

The vascular endothelium occupies a catalog of functions that contribute to the homeostasis
of the cardiovascular system. It is a physically active barrier between circulating blood and …

The modern treatment of cardiac arrest is an increasingly complex medical procedure with a
rapidly changing array of therapeutic approaches designed to restore life to victims of …

Nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing
3 (NLRP3) is a cytosolic protein that nucleates assembly of inflammasome signaling …

Ischemic heart disease is the principal cause of death worldwide and clinically manifests as
myocardial infarction (MI), stable angina, and ischemic cardiomyopathy. Myocardial …

Traumatic brain injury (TBI) is acquired from an external force, which can inflict devastating
effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is …