Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

M Valles-Colomer, C Menni, SE Berry, AM Valdes… - Nature Medicine, 2023 - nature.com
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …

Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision …

W DeGroat, H Abdelhalim, K Patel, D Mendhe… - Scientific reports, 2024 - nature.com
Personalized interventions are deemed vital given the intricate characteristics,
advancement, inherent genetic composition, and diversity of cardiovascular diseases …

[HTML][HTML] Multi-omics integration for the design of novel therapies and the identification of novel biomarkers

T Ivanisevic, RN Sewduth - Proteomes, 2023 - mdpi.com
Multi-omics is a cutting-edge approach that combines data from different biomolecular
levels, such as DNA, RNA, proteins, metabolites, and epigenetic marks, to obtain a holistic …

Risk prediction of cardiovascular events by exploration of molecular data with explainable artificial intelligence

AM Westerlund, JS Hawe, M Heinig… - International Journal of …, 2021 - mdpi.com
Cardiovascular diseases (CVD) annually take almost 18 million lives worldwide. Most lethal
events occur months or years after the initial presentation. Indeed, many patients experience …

Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications

L Wu, JR Sowers, Y Zhang, J Ren - Cardiovascular research, 2023 - academic.oup.com
Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic,
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …

Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?

P Bhattacharya, R Kanagasooriyan… - Current Opinion in …, 2022 - Elsevier
Atherosclerosis is a lipid-driven disease of the artery characterized by chronic non-resolving
inflammation. Despite availability of excellent lipid-lowering therapies, atherosclerosis …

Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases

I Mhatre, H Abdelhalim, W Degroat, S Ashok… - Scientific reports, 2023 - nature.com
Cardiovascular disease (CVD) is caused by a multitude of complex and largely heritable
conditions. Identifying key genes and understanding their susceptibility to CVD in the human …

[HTML][HTML] Biologics and cardiac disease: challenges and opportunities

G Ciucci, A Colliva, R Vuerich, G Pompilio… - Trends in …, 2022 - cell.com
Biologics are revolutionizing the treatment of chronic diseases, such as cancer and
monogenic disorders, by overcoming the limits of classic therapeutic approaches using …

Association of systemic immune inflammation index and system inflammation response index with clinical risk of acute myocardial infarction

X Wei, Z Zhang, J Wei, C Luo - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Background Systemic immune inflammatory index (SII) and systemic inflammatory response
index (SIRI) are combinations of non-specific inflammatory and adaptive immune response …