Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …
They have been tightly linked to microbiome taxonomic and functional composition, with diet …
Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision …
Personalized interventions are deemed vital given the intricate characteristics,
advancement, inherent genetic composition, and diversity of cardiovascular diseases …
advancement, inherent genetic composition, and diversity of cardiovascular diseases …
[HTML][HTML] Multi-omics integration for the design of novel therapies and the identification of novel biomarkers
T Ivanisevic, RN Sewduth - Proteomes, 2023 - mdpi.com
Multi-omics is a cutting-edge approach that combines data from different biomolecular
levels, such as DNA, RNA, proteins, metabolites, and epigenetic marks, to obtain a holistic …
levels, such as DNA, RNA, proteins, metabolites, and epigenetic marks, to obtain a holistic …
Risk prediction of cardiovascular events by exploration of molecular data with explainable artificial intelligence
Cardiovascular diseases (CVD) annually take almost 18 million lives worldwide. Most lethal
events occur months or years after the initial presentation. Indeed, many patients experience …
events occur months or years after the initial presentation. Indeed, many patients experience …
Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications
Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic,
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …
Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?
P Bhattacharya, R Kanagasooriyan… - Current Opinion in …, 2022 - Elsevier
Atherosclerosis is a lipid-driven disease of the artery characterized by chronic non-resolving
inflammation. Despite availability of excellent lipid-lowering therapies, atherosclerosis …
inflammation. Despite availability of excellent lipid-lowering therapies, atherosclerosis …
Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases
I Mhatre, H Abdelhalim, W Degroat, S Ashok… - Scientific reports, 2023 - nature.com
Cardiovascular disease (CVD) is caused by a multitude of complex and largely heritable
conditions. Identifying key genes and understanding their susceptibility to CVD in the human …
conditions. Identifying key genes and understanding their susceptibility to CVD in the human …
[HTML][HTML] Biologics and cardiac disease: challenges and opportunities
G Ciucci, A Colliva, R Vuerich, G Pompilio… - Trends in …, 2022 - cell.com
Biologics are revolutionizing the treatment of chronic diseases, such as cancer and
monogenic disorders, by overcoming the limits of classic therapeutic approaches using …
monogenic disorders, by overcoming the limits of classic therapeutic approaches using …
Association of systemic immune inflammation index and system inflammation response index with clinical risk of acute myocardial infarction
X Wei, Z Zhang, J Wei, C Luo - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Background Systemic immune inflammatory index (SII) and systemic inflammatory response
index (SIRI) are combinations of non-specific inflammatory and adaptive immune response …
index (SIRI) are combinations of non-specific inflammatory and adaptive immune response …