Glycosaminoglycans, a major component of the extracellular matrix molecules in animal
tissues, play important roles in various physiological events. Glycosaminoglycans are found …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential
molecular therapeutic target in treatment of various cancers. Herein, we report the synthesis …

Chondroitin sulfate (CS) dermatan sulfate (DS), and CS/DS hybrid chains are biologically
active like heparan sulfate, and structurally the most complex species of the …

Triazole-based heterocycles have previously been shown to possess significant anticancer
activity in various tumor models. In the present study, we attached a 1, 2, 3-triazole moiety to …

Bioactive dihydropyrimidinones (DHPs) were designed and synthesized by a
multicomponent Biginelli reaction. The reaction was catalyzed by the polarized surface of …

TNF is a pleotropic cytokine known to be involved in the progression of several pro-
inflammatory disorders. Many therapeutic agents have been designed to counteract the …

Histone deacetylases (HDACs) are an attractive drug target for the treatment of human
breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being used in preclinical …

Marine animals are a huge resource of various glycosaminoglycans (GAGs) with specific
structures and functions. A large number of byproducts, such as low-edible mantle, are …

In this study, we developed an on-line reverse-phase high-performance liquid
chromatography–electrospray ionization–mass spectrometry (RP–HPLC–ESI–MS) …