Nanodiscs in membrane biochemistry and biophysics

IG Denisov, SG Sligar - Chemical reviews, 2017 - ACS Publications
Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

[HTML][HTML] Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit

F Brites, M Martin, I Guillas, A Kontush - BBA clinical, 2017 - Elsevier
Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …

[PDF][PDF] Structure of HDL: particle subclasses and molecular components

A Kontush, M Lindahl, M Lhomme… - High Density …, 2015 - library.oapen.org
A molecular understanding of high-density lipoprotein (HDL) will allow a more complete
grasp of its interactions with key plasma remodelling factors and with cell-surface proteins …

HDL-targeted therapies: progress, failures and future

BA Kingwell, MJ Chapman, A Kontush… - Nature reviews Drug …, 2014 - nature.com
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Unraveling the complexities of the HDL lipidome1

A Kontush, M Lhomme, MJ Chapman - Journal of lipid research, 2013 - ASBMB
Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …

HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export

XM Du, MJ Kim, L Hou, W Le Goff… - Circulation …, 2015 - Am Heart Assoc
Rationale: High-density lipoprotein (HDL) is a heterogeneous population of particles.
Differences in the capacities of HDL subfractions to remove cellular cholesterol may explain …

High-density lipoproteins: a consensus statement from the National Lipid Association

PP Toth, PJ Barter, RS Rosenson, WE Boden… - Journal of clinical …, 2013 - Elsevier
For> 4 decades it has been recognized that elevated serum levels of high-density
lipoprotein cholesterol (HDL-C) are associated with reduced risk of cardiovascular disease …

Lipoprotein (a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment

S Lampsas, M Xenou, E Oikonomou, P Pantelidis… - Molecules, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) is a low-density lipoprotein (LDL) cholesterol-like particle bound to
apolipoprotein (a). Increased Lp (a) levels are an independent, heritable causal risk factor …

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond1

AS Shah, L Tan, JL Long, WS Davidson - Journal of lipid research, 2013 - ASBMB
Recent applications of mass spectrometry technology have dramatically increased our
understanding of the proteomic diversity of high density lipoproteins (HDL). Depending on …

Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative …

L Camont, M Lhomme, F Rached… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—High-density lipoprotein (HDL) displays multiple atheroprotective activities and is
highly heterogeneous in structure, composition, and function; the molecular determinants of …