Systemic lupus erythematosus (SLE) is considered an autoimmune disease with multiorgan
involvement. Many advances have been made during the last decade regarding …

Evidence establishes that chronic inflammation and autoimmunity are associated with
cancer development and patients with a primary malignancy may develop autoimmune-like …

Systemic lupus erythematosus is frequently associated with antiphospholipid syndrome.
Patients with lupus-antiphospholipid syndrome are characterized by recurrent …

T regulator lymphocytes (Tregs) play a key role in the maintenance of immune tolerance and
in the development of autoimmune diseases. Expression of Foxp3 is specific for Tregs, and …

Reactive astrocytes are a hallmark of neurodegenerative disease including multiple
sclerosis. It is widely accepted that astrocytes may adopt alternative phenotypes depending …

Background The immunosuppressive tumor microenvironment (TME) of colorectal cancer
(CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence …

Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with
multiorgan involvement. SLE presents many genetic and epigenetic associations and the …

Th17 cells have been casually associated to the pathogenesis of autoimmune disease. We
have previously demonstrated that Rai/ShcC, a member of the Shc family of adaptor …

To date, most studies of Shc family of signaling adaptor proteins have been focused on the
near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and …

Molecular adaptors are proteins implicated in the regulation of the cellular responses to
environmental stimuli, which can be involved in different signaling pathways depending on …