Cigarette smoking-and nicotine-mediated dysregulation in insulin-signaling pathways are
becoming leading health issues associated with morbidity and mortality worldwide. Many …

Blood metabolomics has been widely used for discovering potential metabolite biomarkers
of various diseases. In this study, we report our investigation of the effects of freeze–thaw …

Accumulating evidence suggests that chronic inflammation of metabolic tissues plays a
causal role in obesity-induced insulin resistance. Yet, how specific endothelial factors impact …

Islet vascularization is essential for intact islet function and glucose homeostasis. We have
previously shown that primary cilia directly regulate insulin secretion. However, it remains …

Obesity is an age-independent, lifestyle-triggered, pandemic disease associated with both
endothelial and visceral adipose tissue (VAT) dysfunction leading to cardiometabolic …

Background Diabetes mellitus (DM), a most common chronic disease, is featured with
impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin …

Diabetic cardiomyopathy (DCM) is a severe complication of diabetes mellitus that is
characterized by aberrant myocardial structure and function and is the primary cause of …

Cell death-inducing DNA fragmentation factor-α–like effector C (CIDEC), originally identified
to be a lipid droplet–associated protein in adipocytes, positively associates with insulin …

Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure
commonly ensues in patients with severe obesity and the obese phenotype of preserved …

The vascular endothelium traditionally viewed as a simple physical barrier between the
circulation and tissue is now well established as a key organ mediating whole organism …