The balance between dilatory and constrictive factors is important as it keeps blood vessels
in a homeostatic state. However, altered physiological processes as a result of obesity …

(1) Background: The declined function of peripheral circulating endothelial progenitor cells
(EPCs) in aging individuals resulted in decreased endothelial cell regeneration and …

Anomalous vascular endothelium significantly contributes to various cardiovascular
diseases. VE-cadherin plays a vital role in governing the endothelial barrier. Krüppel-like …

Ageing is an inevitable phenomenon which affects the cellular to the organism level in the
progression of the time. Oxidative stress and inflammation are now widely regarded as the …

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder on a
global scale. Atherosclerosis (AS), a leading cause of cardiovascular diseases, stands as …

Aim During hypertension-induced endothelial dysfunction, periodic mechanical stretching
(MS) activates related inflammatory pathways and leads to endothelial damage, but the …

Diabetes is the ninth leading cause of death, with an estimated 1.5 million deaths worldwide.
Type 2 diabetes (T2D) results from the body's ineffective use of insulin and is largely the …

Objectives Endothelial dysfunction, the earliest vascular alteration, is a consequence of
metabolic disorders associated with obesity. However, it is still unclear whether a proportion …

Overnutrition-induced endothelial inflammation plays a crucial role in high fat diet (HFD)-
induced insulin resistance in animals. Endothelial glycolysis plays a critical role in …

Background: Some pathogenetic risk factors (platelet-derived growth factor (PDGF); tumor
necrosis factor alpha (TNFα); and Endothelin-1 (ET1)) are involved in the development of …