The mRNA vaccine technology era and the future control of parasitic infections

H You, MK Jones, CA Gordon… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Despite intensive long-term efforts, with very few exceptions, the development of effective
vaccines against parasitic infections has presented considerable challenges, given the …

Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination

S Lebu, W Kibone, CC Muoghalu… - PLoS neglected …, 2023 - journals.plos.org
Researchers have raised the possibility that soil-transmitted helminth (STH) infections might
modify the host's immune response against other systemic infections. STH infections can …

Soil-transmitted helminth vaccines: are we getting closer?

A Zawawi, KJ Else - Frontiers in immunology, 2020 - frontiersin.org
Parasitic helminths infect over one-fourth of the human population resulting in significant
morbidity, and in some cases, death in endemic countries. Despite mass drug administration …

Natural-product-based solutions for tropical infectious diseases

O Adegboye, MA Field, A Kupz, S Pai… - Clinical microbiology …, 2021 - Am Soc Microbiol
About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

[HTML][HTML] Preventive chemotherapy and anthelmintic resistance of soil-transmitted helminths–Can we learn nothing from veterinary medicine?

SH Tinkler - One health, 2020 - Elsevier
Current parasite control programs in veterinary species have moved away from mass
anthelmintic treatment approaches due to the emergence of significant anthelmintic …

Metazoan parasite vaccines: present status and future prospects

C Stutzer, SA Richards, M Ferreira, S Baron… - Frontiers in cellular …, 2018 - frontiersin.org
Eukaryotic parasites and pathogens continue to cause some of the most detrimental and
difficult to treat diseases (or disease states) in both humans and animals, while also …

Lessons along the critical path: developing vaccines against human helminths

DJ Diemert, ME Bottazzi, J Plieskatt, PJ Hotez… - Trends in …, 2018 - cell.com
Helminthic parasites are important targets for vaccine research as they infect an estimated 1
billion people worldwide. Despite significant progress in the discovery of defined antigens …

Soil-transmitted helminthic vaccines: Where are we now?

MTJ Wong, NS Anuar, R Noordin, GJ Tye - Acta tropica, 2023 - Elsevier
It has been tested and proven that vaccination is still the best strategy to combat infectious
diseases. However, to date, there are still no vaccines against human soil-transmitted …

In silico design of a polypeptide as a vaccine candidate against ascariasis

FMD Evangelista, AHM van Vliet, SP Lawton… - Scientific reports, 2023 - nature.com
Ascariasis is the most prevalent zoonotic helminthic disease worldwide, and is responsible
for nutritional deficiencies, particularly hindering the physical and neurological development …

Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics

D Sepúlveda‐Crespo, RM Reguera… - Medicinal research …, 2020 - Wiley Online Library
Helminthiasis is one of the gravest problems worldwide. There is a growing concern on less
available anthelmintics and the emergence of resistance creating a major threat to human …