Frontotemporal dementia (FTD) is the second most common cause of dementia following
Alzheimer's disease (AD). Between 20 and 50% of cases are familial. Mutations in MAPT …

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two
neurological diseases which, respectively, and primarily affect motor neurons and …

Heterozygous mutations in the granulin (GRN) gene, resulting in the haploinsufficiency of
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …

Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene
causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a …

Haploinsufficiency of the progranulin protein is a leading cause of frontotemporal lobar
degeneration. Accumulating evidence support a crucial role of progranulin in the lysosome …

Background Mutations resulting in progranulin (PGRN) haploinsufficiency cause
frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a …

ABSTRACT Around 10-15% of patients diagnosed with frontotemporal dementia (FTD) have
a positive family history for FTD with an autosomal dominant pattern of inheritance. Since the …

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar
degeneration (FTLD). PGRN polymorphisms are associated with Alzheimer's disease …

Background and Objectives Limbic predominant age-related TAR DNA binding protein 43
(TDP-43) encephalopathy neuropathologic change (LATE-NC) is a prevalent degenerative …

Progranulin is a highly conserved secreted protein that is expressed in multiple cell types,
both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins …