Minimal residual disease in acute lymphoblastic leukemia: technical and clinical advances

I Della Starza, S Chiaretti, MS De Propris, L Elia… - Frontiers in …, 2019 - frontiersin.org
Introduction: Acute lymphoblastic leukemia (ALL) is the first neoplasm where the
assessment of early response to therapy by minimal residual disease (MRD) monitoring has …

[HTML][HTML] A systematic literature review and meta-analysis of minimal residual disease as a prognostic indicator in adult B-cell acute lymphoblastic leukemia

R Bassan, M Brüggemann, HS Radcliffe… - …, 2019 - ncbi.nlm.nih.gov
Abstract Minimal (or 'measurable') residual disease in acute lymphoblastic leukemia
appears to be a prognostic indicator, with potential value in informing individualized …

Frontline combination of ponatinib and hyper‐CVAD in Philadelphia chromosome‐positive acute lymphoblastic leukemia: 80‐months follow‐up results

H Kantarjian, NJ Short, N Jain, K Sasaki… - American journal of …, 2023 - Wiley Online Library
The combination of ponatinib, a third‐generation BCR:: ABL1 tyrosine kinase inhibitor, with
hyper‐CVAD chemotherapy resulted in high rates of complete molecular remissions and …

Dasatinib-based 2-step induction for adults with Philadelphia chromosome–positive acute lymphoblastic leukemia

I Sugiura, N Doki, T Hata, R Cho, T Ito… - Blood …, 2022 - ashpublications.org
The standard treatment for adults with Philadelphia chromosome–positive (Ph+) acute
lymphoblastic leukemia (ALL) in Japan is imatinib-based chemotherapy followed by …

Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis

Z Shen, X Gu, W Mao, L Yin, L Yang, Z Zhang, K Liu… - BMC cancer, 2018 - Springer
Background This meta-analysis was performed to explore the impact of minimal residual
disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic …

Minimal residual disease status determined by multiparametric flow cytometry pretransplantation predicts the outcome of patients with ALL receiving unmanipulated …

XS Zhao, YR Liu, LP Xu, Y Wang… - American journal of …, 2019 - Wiley Online Library
This study evaluated the effects of pretransplantation minimal residual disease (pre‐MRD)
on outcomes of patients with acute lymphoblastic leukemia (ALL) who underwent …

Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph+ ALL: a study from the adult ALL WG of the JSHCT

S Nishiwaki, K Imai, S Mizuta, H Kanamori… - Bone Marrow …, 2016 - nature.com
To assess the impact of minimal residual disease (MRD) and tyrosine kinase inhibitor (TKI)
administration on allogeneic hematopoietic cell transplantation (allo-HCT) for Ph-positive …

[HTML][HTML] A sequential approach with imatinib, chemotherapy and transplant for adult Ph+ acute lymphoblastic leukemia: final results of the GIMEMA LAL 0904 study

S Chiaretti, A Vitale, M Vignetti, A Piciocchi, P Fazi… - …, 2016 - ncbi.nlm.nih.gov
In the GIMEMA LAL 0904 protocol, adult Philadelphia positive acute lymphoblastic leukemia
patients were treated with chemotherapy for induction and consolidation, followed by …

Final analysis of the JALSG Ph+ ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph+ ALL

Y Hatta, S Mizuta, K Matsuo, S Ohtake, M Iwanaga… - Annals of …, 2018 - Springer
Abstract The Japan Adult Leukemia Study Group (JALSG) Ph+ ALL202 study reported a
high complete remission (CR) rate for Philadelphia chromosome-positive acute …

MRD in ALL: Optimization and Innovations

E Pierce, B Mautner, J Mort, A Blewett, A Morris… - Current Hematologic …, 2022 - Springer
Abstract Purpose of Review Measurable residual disease (MRD) is an important monitoring
parameter that can help predict survival outcomes in acute lymphoblastic leukemia (ALL) …