Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of
choice for treating numerous inflammatory diseases including rheumatoid arthritis. The …

Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that
regulate a wide variety of physiological responses and pathological processes. They are …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

Antiangiogenic agents that block vascular endothelial growth factor (VEGF) signaling are
important components of current cancer treatment modalities but are limited by alternative ill …

Lung cancer is among the most common cancers with a high mortality rate worldwide.
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …

The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation
of various biologically active eicosanoids. The expression of these enzymes vary throughout …

Immune system interactions within the tumour have a key role in the resistance or
sensitization of cancer cells to anti-cancer agents. On the other hand, activation of the …

Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

In recent years, the reports on using nonsteroidal anti-inflammatory drugs (NSAIDs) for
cancer prevention and treatment have been on the rise. In 2017, the US Preventive Services …

Peroxisome proliferator-activated receptors are ligand-activated intracellular transcription
factors that have been implicated in important biological processes such as inflammation …