Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice

L Hases, L Stepanauskaite, M Birgersson… - Communications …, 2023 - nature.com
A high-fat diet can lead to gut microbiota dysbiosis, chronic intestinal inflammation, and
metabolic syndrome. Notably, resulting phenotypes, such as glucose and insulin levels …

Genistein-derived ROS-responsive nanoparticles relieve colitis by regulating mucosal homeostasis

W Fan, S Zhang, Y Wu, T Lu, J Liu, X Cao… - … Applied Materials & …, 2021 - ACS Publications
Disruption of intestinal homeostasis is an important event in the development of
inflammatory bowel disease (IBD), and genistein (GEN) is a candidate medicine to prevent …

Dietary fiber intake and all-cause and cause-specific mortality: An updated systematic review and meta-analysis of prospective cohort studies

F Ramezani, F Pourghazi, M Eslami, M Gholami… - Clinical Nutrition, 2023 - Elsevier
Background Accumulating evidence supports the effects of dietary fiber on the risk of non-
communicable diseases (NCDs). However, there is no updated systematic review and meta …

Implications of estrogen and its receptors in colorectal carcinoma

PK Das, J Saha, S Pillai, AKY Lam, V Gopalan… - Cancer …, 2023 - Wiley Online Library
Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

L Hases, A Archer, R Indukuri, M Birgersson, C Savva… - Scientific reports, 2020 - nature.com
There is a strong association between obesity and colorectal cancer (CRC), especially in
men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is …

[HTML][HTML] Sex difference of colon adenoma pathway and colorectal carcinogenesis

Y Choi, N Kim - The World Journal of Men's Health, 2024 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …

[HTML][HTML] Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family …

K Tang, Z Wu, M Sun, X Huang, J Sun, J Shi, X Wang… - Cancer Letters, 2022 - Elsevier
Dynamic miRNA alteration is known to occur in colitis-associated colon cancer (CAC), while
the molecular mechanisms underpinning how miRNAs modulate the development from …

[HTML][HTML] p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling

X Xu, A Luo, X Lu, M Liu, H Wang, H Song… - Journal of Functional …, 2021 - Elsevier
Abstract p-Hydroxybenzaldehyde (HD), the main active component of Nostoc commune, has
been shown to attenuate dextran sulfate sodium (DSS)-induced experimental colitis …