Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone… - Chemical …, 2015 - ACS Publications
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
CL Masters, DJ Selkoe - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …
Role of water in protein aggregation and amyloid polymorphism
A variety of neurodegenerative diseases are associated with amyloid plaques, which begin
as soluble protein oligomers but develop into amyloid fibrils. Our incomplete understanding …
as soluble protein oligomers but develop into amyloid fibrils. Our incomplete understanding …
Aβ42 and Aβ40: similarities and differences
The abnormal accumulation of amyloid‐β (Aβ) peptide in the brain is one of the most
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …
High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease
In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
Molecular Mechanism of the Inhibition of EGCG on the Alzheimer Aβ1–42 Dimer
T Zhang, J Zhang, P Derreumaux… - The journal of physical …, 2013 - ACS Publications
Growing evidence supports that amyloid β (Aβ) oligomers are the major causative agents
leading to neural cell death in Alzheimer's disease. The polyphenol (−)-epigallocatechin …
leading to neural cell death in Alzheimer's disease. The polyphenol (−)-epigallocatechin …
Toward a molecular theory of early and late events in monomer to amyloid fibril formation
JE Straub, D Thirumalai - Annual review of physical chemistry, 2011 - annualreviews.org
Quantitative understanding of the kinetics of fibril formation and the molecular mechanism of
transition from monomers to fibrils is needed to obtain insights into the growth of amyloid …
transition from monomers to fibrils is needed to obtain insights into the growth of amyloid …
Effects of All-Atom Molecular Mechanics Force Fields on Amyloid Peptide Assembly: The Case of Aβ16–22 Dimer
We investigated the effects of 17 widely used atomistic molecular mechanics force fields
(MMFFs) on the structures and kinetics of amyloid peptide assembly. To this end, we …
(MMFFs) on the structures and kinetics of amyloid peptide assembly. To this end, we …
Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity
The effects of beta-sheet breaker peptides KLVFF and LPFFD on the oligomerization of
amyloid peptides were studied by all-atom simulations. It was found that LPFFD interferes …
amyloid peptides were studied by all-atom simulations. It was found that LPFFD interferes …
Dynamics of an intrinsically disordered protein reveal metastable conformations that potentially seed aggregation
Amyloid fibril deposits of the intrinsically disordered hIAPP peptide are found in 95% of type
II diabetes patients, and the aggregation of this peptide is suggested to induce apoptotic cell …
II diabetes patients, and the aggregation of this peptide is suggested to induce apoptotic cell …