Free-energy landscape of protein oligomerization from atomistic simulations
In the realm of protein–protein interactions, the assembly process of homooligomers plays a
fundamental role because the majority of proteins fall into this category. A comprehensive …
fundamental role because the majority of proteins fall into this category. A comprehensive …
Mechanism of amyloid-β fibril elongation
T Gurry, CM Stultz - Biochemistry, 2014 - ACS Publications
Amyloid-β is an intrinsically disordered protein that forms fibrils in the brains of patients with
Alzheimer's disease. To explore factors that affect the process of fibril growth, we computed …
Alzheimer's disease. To explore factors that affect the process of fibril growth, we computed …
Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs
Aggregation of disordered amyloidogenic peptides into oligomers is the causative agent of
amyloid-related diseases. In solution, disordered protein states are characterized by …
amyloid-related diseases. In solution, disordered protein states are characterized by …
[PDF][PDF] An Internal Disulfide Locks a Misfolded Aggregation-Prone Intermediate in Cataract-Linked Mutants of Human Gamma-D Crystallin
Monday, February 13, 2017 167a aggregation phenomena. Amorphous aggregation of the g-
crystallins in the eye lens causes a widespread disease of aging, cataract. We combined …
crystallins in the eye lens causes a widespread disease of aging, cataract. We combined …
Factors governing fibrillogenesis of polypeptide chains revealed by lattice models
Using lattice models we explore the factors that determine the tendencies of polypeptide
chains to aggregate by exhaustively sampling the sequence and conformational space. The …
chains to aggregate by exhaustively sampling the sequence and conformational space. The …
Fe2+ binding on amyloid β‐peptide promotes aggregation
S Boopathi, P Kolandaivel - Proteins: Structure, Function, and …, 2016 - Wiley Online Library
ABSTRACT The metal ions Zn2+, Cu2+, and Fe2+ play a significant role in the aggregation
mechanism of Aβ peptides. However, the nature of binding between metal and peptide has …
mechanism of Aβ peptides. However, the nature of binding between metal and peptide has …
Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels
Self-assembling peptides (SAP) have drawn an increasing interest in the tissue engineering
community. They display unquestionable biomimetic properties, tailorability and promising …
community. They display unquestionable biomimetic properties, tailorability and promising …
Impact of Cu(II) Binding on Structures and Dynamics of Aβ42 Monomer and Dimer: Molecular Dynamics Study
The classical force field, which is compatible with the Amber force field 99SB, has been
obtained for the interaction of Cu (II) with monomer and dimers of amyloid-β peptides using …
obtained for the interaction of Cu (II) with monomer and dimers of amyloid-β peptides using …
Exploring the Alzheimer amyloid-β peptide conformational ensemble: A review of molecular dynamics approaches
L Tran, T Ha-Duong - Peptides, 2015 - Elsevier
Alzheimer's disease is one of the most common dementia among elderly worldwide. There
is no therapeutic drugs until now to treat effectively this disease. One main reason is due to …
is no therapeutic drugs until now to treat effectively this disease. One main reason is due to …
Effect of the Tottori Familial Disease Mutation (D7N) on the Monomers and Dimers of Aβ40 and Aβ42
Recent experiments have shown that the mutation Tottori (D7N) alters the toxicity, assembly
and rate of fibril formation of the wild type (WT) amyloid beta (Aβ) Aβ40 and Aβ42 peptides …
and rate of fibril formation of the wild type (WT) amyloid beta (Aβ) Aβ40 and Aβ42 peptides …