Exploring the roles of lncRNAs in GBM pathophysiology and their therapeutic potential
CT Stackhouse, GY Gillespie, CD Willey - Cells, 2020 - mdpi.com
Glioblastoma (GBM) remains the most devastating primary central nervous system
malignancy with a median survival of around 15 months. The past decades of research have …
malignancy with a median survival of around 15 months. The past decades of research have …
[HTML][HTML] Implications of advances in studies of O6-methylguanine-DNA-methyltransferase for tumor prognosis and treatment
Y Chen, W Qu, J Tu, H Qi - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
O6-methylguanine-DNA-methyltransferase (MGMT) is a DNA repair enzyme, which reverses
the alkylation of guanine O6 through directtransfer of the methyl group, maintains the gene …
the alkylation of guanine O6 through directtransfer of the methyl group, maintains the gene …
[HTML][HTML] An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases
Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM)
are largely unknown, with a dearth of accurate preclinical models. To address this, we …
are largely unknown, with a dearth of accurate preclinical models. To address this, we …
Differentially methylation of IFI44L gene promoter in Iranian patients with systemic lupus erythematosus and rheumatoid arthritis
M Salesi, MH Dehabadi, R Salehi, A Salehi… - Molecular biology …, 2022 - Springer
Background Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are
multisystemic autoimmune diseases with multifactorial nature. Considering the limitations of …
multisystemic autoimmune diseases with multifactorial nature. Considering the limitations of …
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics
S Tierling, WM Jürgens-Wemheuer, A Leismann… - Clinical …, 2022 - Springer
Background Promoter methylation of the DNA repair gene O 6-methylguanine-DNA
methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma …
methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma …
Age-adjusted Charlson comorbidity index in recurrent glioblastoma: a new prognostic factor?
Background For recurrent glioblastoma (GB) patients, several therapy options have been
established over the last years such as more aggressive surgery, re-irradiation or …
established over the last years such as more aggressive surgery, re-irradiation or …
[HTML][HTML] Revisiting Temozolomide's role in solid tumors: Old is gold?
D Matthaios, I Balgkouranidou, K Neanidis… - Journal of …, 2024 - ncbi.nlm.nih.gov
Temozolomide is an imidazotetrazine with a long history in oncology especially for the high
grade malignant glioma and metastatic melanoma. However, last year's new indications for …
grade malignant glioma and metastatic melanoma. However, last year's new indications for …
MGMT promoter methylation in triple negative breast cancer of the GeparSixto trial
P Jank, C Gehlhaar, L Bianca, F Caterina, S Andreas… - PLoS …, 2020 - journals.plos.org
Triple-negative breast cancer (TNBC) is typically treated with chemotherapeutic agents,
including carboplatin (Cb), an DNA platinating agent. The O6-methylguanine-DNA …
including carboplatin (Cb), an DNA platinating agent. The O6-methylguanine-DNA …
Prognostic utility of lncRNAs (LINC00565 and LINC00641) as molecular markers in glioblastoma multiforme (GBM)
RG Amer, LR Ezz El Arab, D Abd El Ghany… - Journal of Neuro …, 2022 - Springer
Background and aim Glioblastoma multiforme (GBM) is primary brain tumor grade IV
characterized by fast cell proliferation, high mortality and morbidity and most lethal gliomas …
characterized by fast cell proliferation, high mortality and morbidity and most lethal gliomas …
Long-term efficacy of surgical resection with or without adjuvant therapy for treatment of secondary glioblastoma in adults
R Huang, G Li, Y Li, Y Wang, P Yang… - Neuro-Oncology …, 2020 - academic.oup.com
Background There are limited studies on treatment strategies and associated clinical
outcomes in patients with secondary glioblastoma (sGBM). We sought to investigate the …
outcomes in patients with secondary glioblastoma (sGBM). We sought to investigate the …