It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase
activity as well as enhances the production of reactive oxygen species, thus resulting in …

Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy.
In some countries of northern Europe or in North America, it can even affect 6–8% of the …

Abstract Background/Introduction Diabetes and cardiovascular disease develop in concert
with metabolic abnormalities mirroring and causing changes in the vasculature, particularly …

The microcirculation plays a key role in delivering oxygen to and removing metabolic wastes
from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of …

Introduction Crocus sativus L.(saffron) has many biological effects such as antioxidant
property. The present study investigated the immunomodulatory effects of the aqueous …

Mammalian pregnancy involves tremendous de novo maternal vascular construction to
adequately support conceptus development. In early mouse decidua basalis (DB), maternal …

Oxidative stress has been linked to the pathogenesis of the major complications of diabetes
in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a …

Abstract Background Elevated endothelial microparticles (EMPs) levels are surrogate
markers of vascular dysfunction. We analyzed EMPs with apoptotic characteristics and …

Objective Crocin, a bioactive component of saffron, has many biological effects such as
antioxidant property. The present study investigated the anti-hyperglycemic, anti oxidant and …

Endothelial cell (EC) dysfunction is implicated in cardiovascular diseases, including
diabetes. The decrease in nitric oxide (NO) bioavailability is the hallmark of endothelial …