Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …

Circadian rhythms regulate various processes in the human body, including drug
metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the …

The blood-brain barrier (BBB) is a critical interface separating the central nervous system
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …

Glioblastoma (GBM) is the most prevalent malignant primary brain tumor, accounting for
14.2% of all diagnosed tumors and 50.1% of all malignant tumors, and the median survival …

Five decades ago, Franz Halberg conceived the idea of​​ a circadian-based therapy for
cancer, given the differential tolerance to treatment derived from the intrinsic host rhythms …

Albeit the effort to develop targeted therapies for patients with high-grade gliomas (WHO
grades III and IV) is evidenced by hundreds of current clinical trials, radiation remains one of …

Circadian rhythms are internal manifestations of the 24-h solar day that allow for
synchronization of biological and behavioral processes to the external solar day. This …

Research into chronotherapy has seen notable developments over the past decades, with a
clear focus on the identification of circadian clock genes as potential treatment targets …

Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major
successes. This underlines the necessity to understand glioblastoma biology on other levels …

The Period (PER) gene family is one of the core components of the circadian clock, with
substantial correlations between the PER genes and cancers identified in extensive …