Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Hyperphosphorylation and aggregation of the microtubule‐associated protein tau in brain,
are pathological hallmarks of a large family of neurodegenerative disorders, named …

Insulin signaling in central nervous system (CNS) has emerged as a novel field of research
since decreased brain insulin levels and/or signaling were associated to impaired learning …

Introduction: Diabetes mellitus is a risk for brain injury. Brain injury is associated with acute
and chronic hyperglycaemia, insulin resistance, hyperinsulinemia, diabetic ketoacidosis …

Glucose uptake and energy metabolism in the brain are regulated by insulin and insulin-like
growth factors (IGF). Recent studies demonstrated progressive deficiencies in brain insulin …

Sequential cleavages of the β‐amyloid precursor protein cleaving enzyme 1 (BACE1) by β‐
secretase and γ‐secretase generate the amyloid β‐peptides, believed to be responsible of …

Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up‐regulates expression
of the β‐site APP cleaving enzyme (BACE‐1), an aspartyl protease responsible for the β …

Markers of oxidative damage have been detected in brain tissue from patients with
Alzheimer disease (AD) and other neurodegenerative disorders. These findings implicate …

The specific CB 2 cannabinoid receptor agonist JWH-133 induced cognitive improvement in
double AβPP/PS1 transgenic mice, a genetic model of Alzheimer's disease. This effect was …

Hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main
pathologic hallmarks in Alzheimer's disease (AD) and other tauopathies, including Pick's …