Health professionals are encouraged to take the ESC/EACTS Guidelines fully into account
when exercising their clinical judgment, as well as in the determination and the …

As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Arterial hypertension is a leading cause of death globally. Due to ageing, the rising
incidence of obesity, and socioeconomic and environmental changes, its incidence …

Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Objective Transitions in the spectrum of valvular heart diseases (VHDs) in developed
countries over the 20th century have been reported from clinical case series, but large …

Calcific aortic valve stenosis (CAVS) is common in the ageing population and set to become
an increasing economic and health burden. Once present, it inevitably progresses and has a …

731 F. Beyersdorf and A. Vahanian et al./European Journal of Cardio-Thoracic Surgery
guidelines, which is freely available via the ESC and EACTS website and hosted on the EHJ …

Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The
only treatment shown to improve survival is aortic valve replacement; however, before …

Background: Left ventricular (LV) hypertrophy, a key process in human cardiac disease,
results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis) …