The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

High-throughput 3D microfluidic cell culture systems can be designed to model aspects of
human tissues and organs and may thus serve as non-clinical evaluation tools. They benefit …

Background T-cell retargeting to eliminate CEACAM5-expressing cancer cells via
CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly …

Background Cancer immunotherapy is receiving worldwide attention for its induction of an
anti-tumor response. However, it has had limited efficacy in some patients who acquired …

Current in vitro models struggle to balance the complexity of human diseases with suitability
for large-scale drug tests. While 3D cultures simulate human tissues, they lack cellular …

Glioblastoma (GBM) is the most aggressive and prevalent primary malignant tumor of the
central nervous system. Traditional chemotherapy has poor therapeutic effects and …

Fungal corneal ulcer is one of the leading causes of corneal blindness in developing
countries. Corneal scars such as leukoplakia are formed due to inflammation, oxidative …

Hybrid living biobots consisting of active cells hold promise for significant applications as, for
example, intelligent devices in medical engineering and organisms with specific functions in …

Human induced pluripotent stem cell (hiPSC)-derived mesenchymal stem cells (iMSCs) are
ideal candidates for the production of standardised and scalable bioengineered bone grafts …

Cancer incidence and mortality are increasing globally. Cancer immunotherapies, such as
immune checkpoint inhibitors and adoptive cell therapy, have been recognized as a …