[HTML][HTML] Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Renal delivery of pharmacologic agents during machine perfusion to prevent ischaemia-reperfusion injury: from murine model to clinical trials

R Franzin, A Stasi, M Fiorentino, S Simone… - Frontiers in …, 2021 - frontiersin.org
Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …

[HTML][HTML] Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review

A Fard, R Pearson, R Lathan… - Transplant …, 2022 - frontierspartnerships.org
Ex-vivo normothermic perfusion (EVNP) is an emerging strategy in kidney preservation that
enables resuscitation and viability assessment under pseudo-physiological conditions prior …

Preservation of organs to be transplanted: An essential step in the transplant process

M Lepoittevin, S Giraud, T Kerforne, B Barrou… - International Journal of …, 2022 - mdpi.com
Organ transplantation remains the treatment of last resort in case of failure of a vital organ
(lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for …

Current evidence and future perspectives to implement continuous and end-ischemic use of normothermic and oxygenated hypothermic machine perfusion in clinical …

M Foguenne, S MacMillan, P Kron, J Nath… - Journal of clinical …, 2023 - mdpi.com
The use of high-risk renal grafts for transplantation requires the optimization of pretransplant
assessment and preservation reconditioning strategies to decrease the organ discard rate …

Prolonged controlled oxygenated rewarming improves immediate tubular function and energetic recovery of porcine kidneys during normothermic machine perfusion

B Ogurlu, CC Pamplona, IM Van Tricht… - …, 2023 - journals.lww.com
Background. Normothermic machine perfusion (NMP) is typically performed after a period of
hypothermic preservation, which exposes the kidney to an abrupt increase in temperature …

Taurine as Antioxidant in a Novel Cell-and Oxygen Carrier-Free Perfusate for Normothermic Machine Perfusion of Porcine Kidneys

L Zarnitz, BM Doorschodt, L Ernst, A Hosseinnejad… - Antioxidants, 2023 - mdpi.com
Donor organ-shortage has resulted in the increased use of marginal grafts; however,
normothermic machine perfusion (NMP) holds the potential for organ viability assessment …

Normothermic machine perfusion of kidneys: current strategies and future perspectives

F Messner, C Bogensperger, JP Hunter… - Current opinion in …, 2022 - journals.lww.com
Normothermic machine perfusion of kidneys: current strategie... : Current Opinion in Organ
Transplantation Normothermic machine perfusion of kidneys: current strategies and future …

Artificial oxygen carriers in organ preservation: dose dependency in a rat model of ex‐vivo normothermic kidney perfusion

J Jägers, M Kirsch, M Cantore, O Karaman… - Artificial …, 2022 - Wiley Online Library
Introduction Organ preservation through ex‐vivo normothermic perfusion (EVNP) with
albumin‐derived perfluorocarbon‐based artificial oxygen carriers (A‐AOCs) consisting of …

Normothermic ex vivo perfusion of deceased donor kidneys and its clinical potential in kidney transplantation outcomes

M Unes, K Kurashima, Y Caliskan… - … Journal of Artificial …, 2023 - journals.sagepub.com
In recent years, normothermic machine perfusion (NMP) has emerged in conversation
surrounding organ preservation and transplantation techniques with the goal of improving …