Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …

Dry eye disease (DED), keratoconjunctivitis sicca or dysfunctional tear syndrome, is the most
prevalent ophthalmic disease which affects a substantial segment of people worldwide with …

Contact lens-related complications are common, affecting around one third of wearers,
although most are mild and easily managed. Contact lenses have well-defined anatomical …

Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

Ophthalmic inflammatory diseases, including conjunctivitis, keratitis, uveitis, scleritis, and
related conditions, pose considerable challenges to effective management and treatment …

Background Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry
eye disease (DED) stems from a loss‐of‐tear film homeostasis and is frequently seen in …

Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than
ever given the rapid pace of modernization, which is directly associated with many of the …

Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS; the most common
phenotype of corticobasal degeneration) are tauopathies with a relentless course, usually …

The eye is an isolated and complex organ, with multiple robust anatomical and physiological
barriers on the ocular surface which protect it from noxious insults such as the blink reflex …

Purpose: The purpose of this trial was to evaluate the safety and efficacy of OC-01
(varenicline solution), a nicotinic acetylcholine receptor agonist nasal spray, on signs and …