Role of B cells as antigen presenting cells

I Rastogi, D Jeon, JE Moseman, A Muralidhar… - Frontiers in …, 2022 - frontiersin.org
B cells have been long studied for their role and function in the humoral immune system.
Apart from generating antibodies and an antibody-mediated memory response against …

Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

A Marra, D Trapani, G Viale, C Criscitiello… - NPJ breast …, 2020 - nature.com
Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple
entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite …

Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

SA Apostolidis, M Kakara, MM Painter, RR Goel… - Nature medicine, 2021 - nature.com
SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune
protection against COVID-19. However, little is known about SARS-CoV-2 mRNA vaccine …

Dual effect of immune cells within tumour microenvironment: pro-and anti-tumour effects and their triggers

AC Peña-Romero, E Orenes-Piñero - Cancers, 2022 - mdpi.com
Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Prognostic significance of tumor-infiltrating B cells and plasma cells in human cancer

MCA Wouters, BH Nelson - Clinical Cancer Research, 2018 - AACR
There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

Reassessing B cell contributions in multiple sclerosis

R Li, KR Patterson, A Bar-Or - Nature immunology, 2018 - nature.com
There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

B lymphocytes and cancer: a love–hate relationship

GJ Yuen, E Demissie, S Pillai - Trends in cancer, 2016 - cell.com
B Lymphocytes and Cancer: A Love–Hate Relationship: Trends in Cancer Skip to Main Content
Advertisement Trends in Cancer This journal offers authors two options (open access or …

Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer

C Germain, S Gnjatic, F Tamzalit… - American journal of …, 2014 - atsjournals.org
Rationale: It is now well established that immune responses can take place outside of
primary and secondary lymphoid organs. We previously described the presence of tertiary …

B‐cell Therapy for Multiple Sclerosis: Entering an era

AL Greenfield, SL Hauser - Annals of neurology, 2018 - Wiley Online Library
Monoclonal antibodies that target CD20 expressing B cells represent an important new
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …

CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27 Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian …

JS Nielsen, RA Sahota, K Milne, SE Kost… - Clinical cancer …, 2012 - AACR
Purpose: Tumor-infiltrating lymphocytes (TIL), in particular CD8+ T cells and CD20+ B cells,
are strongly associated with survival in ovarian cancer and other carcinomas. Although …