Abstract Introduction Hyperthyroid Graves' disease (GD) is a B-cell-mediated condition
caused by TSH receptor antibodies (TRAb), which decline when GD remits. Anti-CD20 …

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and neurodegenerative
disease affecting the central nervous system (CNS), often characterized by the accumulation …

The generation of Ab-secreting plasma cells depends critically on CD4 T-follicular helper
(TFH) cells during the germinal center reaction. Germinal center TFH cells share functional …

Tuberculosis (TB) remains a serious threat to public health, causing 2 million deaths
annually world-wide. The control of TB has been hindered by the requirement of long …

Tumour-infiltrating immune cells have been widely implicated to play a significant role in
carcinogenesis, through both pro-or anti-tumour effects. The multi-faceted effects of lung …

After allogeneic blood or bone marrow transplantation, donor T cells interact with a distorted
antigen-presenting cell (APC) environment in which some, but not all, host APCs are …

Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver
disease, and cancer. It is also linked with more severe complications from infections …

B cells have both Ab-dependent and Ab-independent functions in systemic autoimmune
diseases, including systemic lupus erythematosus (SLE). Ab-independent functions are …

A healthy ocular surface environment is essential to preserve visual function, and as such
the eye has evolved a complex network of mechanisms to maintain homeostasis …

Whereas our understanding of the skin immune system has increased exponentially in
recent years, the role of B cells in cutaneous immunity remains poorly defined. Recent …