Objectives. B cells are central to the pathology of ANCA-associated vasculitis (AAV), a
disease characterized by autoantibodies and effectively treated by rituximab. In addition to …

Upon implantation into a patient, any biomaterial induces a cascade of immune responses
that influences the outcome of that device. This cascade depends upon several factors …

Acute lung injury (ALI) is characterized by the influx of protein-rich edematous fluid into the
airspaces due to increased permeability of the alveolar-capillary barrier. Inflammatory …

Successful vaccination relies on immune memory, a core competence of the adaptive
immune system. This review summarizes the current knowledge about the adaptive immune …

A common finding when measuring T cell immunity to enteric bacterial vaccines in humans
is the presence of background responses among individuals before immunization. Yet the …

Our understanding of the B-cell subsets found in human blood and their functional
significance has advanced greatly in the past decade. This has been aided by the evolution …

Melanoma is one of the most aggressive and therapy-resistant types of cancer, the
incidence rate of which grows every year. However, conventional methods of chemo-and …

PURPOSE. The purpose of this study was to determine if autoantibodies play a role in the
immunopathogenesis of experimental dry eye disease. METHODS. Dry eye was induced by …

Itch or itchy E3 ubiquitin ligase was initially discovered by genetic studies on the mouse coat
color changes, and its deletion results in an itchy phenotype with constant skin scratching …

Regulatory B cells (Breg) are essential players in tolerance and immune homeostasis.
However, lack of specific Breg markers limit their potential in clinical settings. Mesenchymal …